AChE/BChE-IN-29

AChE/BChE-IN-29 is an inhibitor of AChE/BChE. This compound exhibits balanced dual cholinesterase inhibitory activity, with an IC50 value of 2.1 μM against electric eel acetylcholinesterase (eeAChE) and 6.3 μM against horse serum butyrylcholinesterase (eqBChE) . In an E. coli cell model, AChE/BChE-IN-29 effectively inhibits the aggregation of amyloid-β (Aβ42) and tau protein. It is a useful agent for Alzheimer's disease (AD) research.