LMDP10
LMDP10 is an orally active 3-aminoquinazoline derivative that activates the Keap1-Nrf2 pathway. It binds to Keap1, inhibiting the Keap1-Nrf2 interaction and subsequently activating the Nrf2 pathway. This leads to increased levels of Nrf2, SOD, and GSH, while reducing MDA and TNF-α levels. As a result, LMDP10 alleviates neurodegeneration and improves memory in Alzheimer's disease (AD) rat models. LMDP10 is applicable for Alzheimer's disease (AD) research.
Product Specifications
CAS Number
2760446-25-9
Smiles
O=C (NN1C (=O) C=2C=CC=CC2N=C1CN (C3=CC=C (F) C=C3) C (=O) C=4C=CC=CC4) C=5C=CC=CC5
Molecular Formula
C29H21FN4O3
Molecular Weight
492.51
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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