TJU103

TJU103 is a CD4 inhibitor that impedes the functionality of CD4 during activation, thereby suppressing autoreactive CD4+ T cells. In a mouse model of experimental autoimmune encephalomyelitis (EAE), TJU103 reduces monocyte infiltration in brain and spinal tissues. It downregulates Th1 and Th2 cytokine levels against proteolipid protein epitope 139-151 (PLPe) and exhibits inhibitory effects both after EAE symptom onset and subsequent antigen stimulation. TJU103 is applicable in research on autoimmune diseases such as EAE and multiple sclerosis (MS) .