JAK2-IN-14
JAK2-IN-14 is an orally effective JAK2 inhibitor with an IC50 of 2 nM. It exhibits selectivity for JAK2 over JAK1, JAK3, and TYK2 by factors of 89.5, 80.5, and 51 times, respectively. JAK2-IN-14 inhibits the STAT5 signaling pathway and can cause tumor cell cycle arrest and apoptosis (apoptosis) . It is applicable in the research of myeloproliferative neoplasms (MPN) .
Product Specifications
CAS Number
3087335-24-5
Smiles
N1=CC (=C2NC1=NC=3C=CC (=C (OCCCCN4N=CC2=C4) C3) N5CCN (CC5) CC6CC6) C
Molecular Formula
C26H33N7O
Molecular Weight
459.6
Storage Conditions
-20°C
Notes
For research use only.
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