P-gp-IN-32

P-gp-IN-32 is a P-glycoprotein (P-gp) inhibitor with low cytotoxicity, demonstrating significant multidrug resistance (MDR) reversal activity against doxorubicin in MCF7/ADR cells. It has an IC50 value of 0.11 μM and a resistance reversal factor (RF) of 215.9. P-gp-IN-32 interacts directly with P-gp, inducing conformational changes and inhibiting its efflux function. This compound is applicable in cancer research, including studies on breast cancer.