EGFR/COX_2-IN_3

EGFR/COX-2-IN-3 is a highly selective dual-target inhibitor of EGFR and COX-2, with IC50 values of 0.098 μM and 0.05 μM for the two targets respectively. Pharmacological prediction Results: show that it possesses good oral bioavailability and blood-brain barrier penetration ability. Meanwhile, it exhibits significant analgesic effects and anti-glioblastoma pharmacological activity, and can be applied to mechanism and efficacy research of glioblastoma and other tumors.