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Opitor-0

Opitor-0 is a highly selective OPA1 GTPase inhibitor with an IC50 of 3 μM. Opitor-0 disrupts the stability of OPA1 oligomers, triggering mitochondrial cristae remodeling and fragmentation, which leads to massive release of cytochrome c and subsequently induces apoptosis. In anticancer studies, Opitor-0 has been shown to exhibit synergistic effects when combined with the Bcl-2 inhibitor ABT-737 or Venetoclax.

Product Specifications

Purity

98.61% (May vary between batches)

Smiles

CC1=NN (C2=C1C=C (C (NC3=C (C) N (CC4=CC=CC=C4) N (C5=CC=CC=C5) C3=O) =O) S2) C6=CC=CC=C6

Molecular Formula

C30H25N5O2S

Molecular Weight

519.62

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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