Opitor-0
Opitor-0 is a highly selective OPA1 GTPase inhibitor with an IC50 of 3 μM. Opitor-0 disrupts the stability of OPA1 oligomers, triggering mitochondrial cristae remodeling and fragmentation, which leads to massive release of cytochrome c and subsequently induces apoptosis. In anticancer studies, Opitor-0 has been shown to exhibit synergistic effects when combined with the Bcl-2 inhibitor ABT-737 or Venetoclax.
Product Specifications
Purity
98.61% (May vary between batches)
Smiles
CC1=NN (C2=C1C=C (C (NC3=C (C) N (CC4=CC=CC=C4) N (C5=CC=CC=C5) C3=O) =O) S2) C6=CC=CC=C6
Molecular Formula
C30H25N5O2S
Molecular Weight
519.62
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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