M6766
M6766 is a selective and potent inhibitor of endoplasmic reticulum oxidoreductase 1α (ERO1α), exhibiting an IC50 of 1.4 uM and a KD of 1.1 uM. It also inhibits ERO1β with an IC50 of 7.2 uM. M6766 exerts its inhibitory effect by binding to the flavin adenine dinucleotide (FAD) -binding pocket of ERO1α. Functionally, M6766 suppresses granule secretion, αIIbβ3 integrin activation, Ca2+ mobilization, and platelet aggregation. It serves as a significant chemical probe for investigating the molecular pathways of arterial thrombosis and neurological disorders, such as ischemic stroke.
Product Specifications
CAS Number
696628-90-7
Purity
99.17% (May vary between batches)
Smiles
N#CC=1C2=NC=3C=CC=CC3N2C (SC4=NN=CN4C) =C5C1CCCC5
Molecular Formula
C19H16N6S
Molecular Weight
360.44
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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