M6766

M6766 is a selective and potent inhibitor of endoplasmic reticulum oxidoreductase 1α (ERO1α), exhibiting an IC50 of 1.4 uM and a KD of 1.1 uM. It also inhibits ERO1β with an IC50 of 7.2 uM. M6766 exerts its inhibitory effect by binding to the flavin adenine dinucleotide (FAD) -binding pocket of ERO1α. Functionally, M6766 suppresses granule secretion, αIIbβ3 integrin activation, Ca2+ mobilization, and platelet aggregation. It serves as a significant chemical probe for investigating the molecular pathways of arterial thrombosis and neurological disorders, such as ischemic stroke.