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SB405483

SB405483 is a CRBN (cereblon) orthosteric ligand-binding enhancer that promotes the ubiquitination and proteasomal degradation of CRBN substrates (such as CK1α, Wee1, and IKZF1/3) by stabilizing the CRBN protein conformation and enhancing its binding affinity for substrates. SB405483 can be used in cancer research, such as in multiple myeloma and acute myeloid leukemia.

Product Specifications

Purity

99.70% (May vary between batches)

Smiles

O=C (NC1=C (O) C=C (C#N) C=C1) NC (N=CC=C2) =C2OCC3=CC=CC=C3

Molecular Formula

C20H16N4O3

Molecular Weight

360.37

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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