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LFM-A13

LFM-A13 is a highly selective inhibitor of the non-receptor tyrosine kinase BTK (Bruton's tyrosine kinase) (IC50 = 2.5 μM) . It irreversibly severs the downstream signaling network of the B-cell receptor (BCR) by targeted binding to the BTK kinase catalytic domain, exhibiting excellent anti-leukemic and immunomodulatory effects in models of acute/chronic lymphocytic leukemia and severe autoimmune diseases.

Product Specifications

CAS Number

62004-35-7

Purity

99.50% (May vary between batches)

Smiles

N#CC (C (=O) NC1=CC (Br) =CC=C1Br) =C (O) C

Molecular Formula

C11H8Br2N2O2

Molecular Weight

360

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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