(Iso) -TRPV4 antagonist 5
(Iso) -TRPV4 antagonist 5 are potent, selective, and orally active transient receptor potential vanilloid 4 (TRPV4) channel blockers for the treatment of pulmonary edema and respiratory diseases. This compound was discovered through optimization of a spirocarbamate lead designed to reduce interstitial lung fluid. Research on its derivatives and related compounds primarily focuses on improving metabolic stability, reducing lipophilicity to enhance clearance, and increasing potency.
Product Specifications
CAS Number
3026084-13-6
Purity
99.63% (May vary between batches)
Smiles
C ([C@@]1 (C) C[C@@]2 (CN (C (=O) O2) C=3C=NC (C (C) (C) O) =CN3) CC[C@@H]1F) N4C=5C (N=C4) =CC=C (C#N) C5
Molecular Formula
C25H27FN6O3
Molecular Weight
478.52
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
EAKT1-100 100 Tests
EnzyFluo™ Human/Mouse AKT1 (S473) Phosphorylation ELISA Kit
Sign In for Pricing
View Details 
BNC881778-100 1x 100 µL
Spectrin beta III (SPTBN2) (SPTBN2/1778), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
![DPPA4 Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI2F6]](https://cdn.genprice.uk/products/937/68dd1b75061270361ea19c5d/imageurl/ta800036am.webp)
TA800036AM 100 µL
DPPA4 Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI2F6]
Sign In for Pricing
View Details 
LY400495 100 µg
Cyclin E1 (CCNE1) (NM_001238) Human Over-expression Lysate
Sign In for Pricing
View Details