(Iso) -TRPV4 antagonist 5
(Iso) -TRPV4 antagonist 5 are potent, selective, and orally active transient receptor potential vanilloid 4 (TRPV4) channel blockers for the treatment of pulmonary edema and respiratory diseases. This compound was discovered through optimization of a spirocarbamate lead designed to reduce interstitial lung fluid. Research on its derivatives and related compounds primarily focuses on improving metabolic stability, reducing lipophilicity to enhance clearance, and increasing potency.
Product Specifications
CAS Number
3026084-13-6
Purity
99.63% (May vary between batches)
Smiles
C ([C@@]1 (C) C[C@@]2 (CN (C (=O) O2) C=3C=NC (C (C) (C) O) =CN3) CC[C@@H]1F) N4C=5C (N=C4) =CC=C (C#N) C5
Molecular Formula
C25H27FN6O3
Molecular Weight
478.52
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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