VLX 1500
VLX 1500 is a potent deubiquitinating enzyme (DUBs) inhibitor designed to overcome resistance to traditional proteasome inhibitors. It triggers ER stress-mediated apoptosis by specifically blocking USP14/UCHL5 activity on the 19S regulatory particle, leading to a lethal accumulation of ubiquitinated proteins, widely used in drug target screening for relapsed hematological malignancies.
Product Specifications
CAS Number
330450-45-8
Smiles
O=C (N1CC (C (C (C1) =CC2=CC=C ([N+] ([O-]) =O) C=C2) =O) =CC3=CC=C ([N+] ([O-]) =O) C=C3) C=C
Molecular Formula
C22H17N3O6
Molecular Weight
419.39
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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