3PO

3PO is an inhibitor of PFKFB3. 3PO attenuates the proliferation of several cancer cell lines with IC50s of 1.4-24 μmol/L. 3PO suppresses glucose uptake and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+ and NADH. 3PO can be used for the research of cancer[1].

Product Specifications

CAS Number

[18550-98-6]

UNSPSC

12352005

Hazard Statement

H302

Target

Autophagy

Type

Reference compound

Related Pathways

Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/3PO.html

Concentration

10mM

Purity

99.85

Solubility

DMSO : 60 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=NC=C1)/C=C/C2=CC=CN=C2

Molecular Formula

C13H10N2O

Molecular Weight

210.23

Precautions

H302

References & Citations

[1]Clem B, et al. Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth. Mol Cancer Ther. 2008 Jan;7 (1) :110-20.|[2]Schoors S, et al. Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis. Cell Metab. 2014 Jan 7;19 (1) :37-48.|[3]Lea MA, Inhibition of Growth of Bladder Cancer Cells by 3- (3-Pyridinyl) -1- (4-pyridinyl) -2-propen-1-one in Combination with Other Compounds Affecting Glucose Metabolism. Anticancer Res. 2015 Nov;35 (11) :5889-99.