3PO
3PO is an inhibitor of PFKFB3. 3PO attenuates the proliferation of several cancer cell lines with IC50s of 1.4-24 μmol/L. 3PO suppresses glucose uptake and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+ and NADH. 3PO can be used for the research of cancer[1].
Product Specifications
CAS Number
18550-98-6
UNSPSC
12352005
Hazard Statement
H302
Target
Autophagy
Type
Reference compound
Related Pathways
Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/3PO.html
Concentration
10mM
Purity
99.85
Solubility
DMSO : 60 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=NC=C1)/C=C/C2=CC=CN=C2
Molecular Formula
C13H10N2O
Molecular Weight
210.23
Precautions
H302
References & Citations
[1]Clem B, et al. Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth. Mol Cancer Ther. 2008 Jan;7 (1) :110-20.|[2]Schoors S, et al. Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis. Cell Metab. 2014 Jan 7;19 (1) :37-48.|[3]Lea MA, Inhibition of Growth of Bladder Cancer Cells by 3- (3-Pyridinyl) -1- (4-pyridinyl) -2-propen-1-one in Combination with Other Compounds Affecting Glucose Metabolism. Anticancer Res. 2015 Nov;35 (11) :5889-99.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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