Creosol

Creosol (2-Methoxy-4-methylphenol) is an endogenous metabolite that acts as an important chemical intermediate and potential biofuel mainly derived from lignocellulosic biomass. Creosol is blood brain barrier penetrable[1][2][3].

Product Specifications

CAS Number

[93-51-6]

Product Name Alternative

2-Methoxy-4-methylphenol

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Akt; Endogenous Metabolite; ERK; FAK; p38 MAPK; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/creosol.html

Concentration

10mM

Purity

99.85

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC=C(C)C=C1OC

Molecular Formula

C8H10O2

Molecular Weight

138.17

Precautions

H302, H315, H319

References & Citations

[1]Yin J, et al. Purification of creosol applying green heterogeneous extraction technology[J]. Journal of Chemical Technology & Biotechnology, 2022, 97 (10) : 2945-2951.|[2]Meylemans HA, Groshens TJ, Harvey BG. Synthesis of renewable bisphenols from creosol. ChemSusChem. 2012 Jan 9;5 (1) :206-10. |[3]Aliu E, et al. Mild-Temperature hydrodeoxygenation of vanillin a typical bio-oil model compound to Creosol a potential future biofuel[J]. Catalysis Today, 2021, 379: 70-79.|[4]Lee JH, et al., Fucoidan Rescues p-Cresol-Induced Cellular Senescence in Mesenchymal Stem Cells via FAK-Akt-TWIST Axis. Mar Drugs. 2018 Apr 6;16 (4) :121.|[5]Tevzadze G, et al. Gut neurotoxin p-cresol induces brain-derived neurotrophic factor secretion and increases the expression of neurofilament subunits in PC-12 cells. AIMS Neurosci. 2021 Dec 23;9 (1) :12-23. |[6]Bermudez-Martin P, et al., The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiota. Microbiome. 2021 Jul 8;9 (1) :157. |[7]Chang MC, et al., Antiplatelet effect by p-cresol, a uremic and environmental toxicant, is related to inhibition of reactive oxygen species, ERK/p38 signaling and thromboxane A2 production. Atherosclerosis. 2011 Dec;219 (2) :559-65.