Ethynylcytidine

Ethynylcytidine is a nucleoside analog and a highly potent inhibitor of RNA synthesis, exerting inhibitory effects on RNA polymerases I, II and III. It exhibits significant anti-tumor activity in a variety of cancer models and also serves as an important click chemistry reagent; its molecular structure contains an alkyne group, which can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-modified molecules.