NCC007

NCC007 is a dual casein kinase Iα (CKIα) and δ (CKIδ) inhibitor with IC50s of 1.8 and 3.6 μM, respectively. NCC007 can be used in research of modulating mammalian circadian rhythms[1].

Product Specifications

CAS Number

[2342583-66-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Casein Kinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Stem Cell/Wnt

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ncc007.html

Concentration

10mM

Purity

99.22

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

CN(C)CCNC1=NC2=C(N=CN2C(C)C3CC3)C(NCC4=CC(C(F)(F)F)=CC=C4)=N1

Molecular Formula

C22H28F3N7

Molecular Weight

447.50

Precautions

H302, H315, H319, H335

References & Citations

[1]Lee JW, et al. Chemical Control of Mammalian Circadian Behavior through Dual Inhibition of Casein Kinase Iα and δ. J Med Chem. 2019 Feb 28;62 (4) :1989-1998.