NCC007
NCC007 is a dual casein kinase Iα (CKIα) and δ (CKIδ) inhibitor with IC50s of 1.8 and 3.6 μM, respectively. NCC007 can be used in research of modulating mammalian circadian rhythms[1].
Product Specifications
CAS Number
[2342583-66-6]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Casein Kinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ncc007.html
Concentration
10mM
Purity
99.22
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CN(C)CCNC1=NC2=C(N=CN2C(C)C3CC3)C(NCC4=CC(C(F)(F)F)=CC=C4)=N1
Molecular Formula
C22H28F3N7
Molecular Weight
447.50
Precautions
H302, H315, H319, H335
References & Citations
[1]Lee JW, et al. Chemical Control of Mammalian Circadian Behavior through Dual Inhibition of Casein Kinase Iα and δ. J Med Chem. 2019 Feb 28;62 (4) :1989-1998.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CK1
Available Sizes
Curated Selection
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