SIRT7 inhibitor 97491

SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.[1].

Product Specifications

CAS Number

[1807758-81-1]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Apoptosis; Sirtuin

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sirt7-inhibitor-97491.html

Purity

98.81

Solubility

DMSO : 500 mg/mL (ultrasonic)

Smiles

NC1=CC(NC2=NC=C(C3=CC=C(Cl)C=C3)O2)=CC=C1

Molecular Formula

C15H12ClN3O

Molecular Weight

285.73

Precautions

H315, H319

References & Citations

[1]Ji-Hye Kim, et al. Identification of a Novel SIRT7 Inhibitor as Anticancer Drug Candidate. Biochem Biophys Res Commun. 2019 Jan 8;508 (2) :451-457.