SIRT7 inhibitor 97491
SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.[1].
Product Specifications
CAS Number
1807758-81-1
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Apoptosis; Sirtuin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sirt7-inhibitor-97491.html
Purity
98.81
Solubility
DMSO : 500 mg/mL (ultrasonic)
Smiles
NC1=CC(NC2=NC=C(C3=CC=C(Cl)C=C3)O2)=CC=C1
Molecular Formula
C15H12ClN3O
Molecular Weight
285.73
Precautions
H315, H319
References & Citations
[1]Ji-Hye Kim, et al. Identification of a Novel SIRT7 Inhibitor as Anticancer Drug Candidate. Biochem Biophys Res Commun. 2019 Jan 8;508 (2) :451-457.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT7
Available Sizes
Frequently Asked Questions
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