SN38- (PEG) 2-Pom-α

SN38- (PEG) 2-Pom-α is a selective PROTACRPL15 degrader. It induces ubiquitin-mediated degradation of RPL15 without affecting TOP1. Additionally, SN38- (PEG) 2-Pom-α can prompt cancer cells to secrete damage-associated molecular patterns (DAMPs), activating the cGAS-STING pathway in dendritic cells. In a human CRBN-expressing mouse melanoma model, SN38- (PEG) 2-Pom-α demonstrates synergistic tumor growth inhibition when used in combination with anti-PD-1 antibodies. This compound is valuable for melanoma research.