PROTAC Sirt2 Degrader-2

PROTACSirt2 Degrader-2 is a potent and selective PROTAC degrader that targets SIRT2. It exhibits strong antiproliferative activity both in vitro and in vivo. This compound significantly enhances H4K16Ac levels and effectively inhibits colony formation and migration, induces cell cycle arrest, and promotes apoptosis. By indirectly degrading SIRT2 and blocking downstream protein phosphorylation, PROTACSirt2 Degrader-2 disrupts the AKT/mTOR signaling pathway, impeding signaling cascades and inhibiting tumor progression. This compound is used in ovarian cancer research.