PROTAC HPK1 Degrader-7

PROTACHPK1 Degrader-7 (compound D02) is a potent and selective PROTACHPK1 degrader with a DC50 of 3.07 nM, showing selectivity for GLK. It induces HPK1 degradation in a CRBN and proteasome-dependent manner. Additionally, PROTACHPK1 Degrader-7 inhibits the phosphorylation of SLP-76 and stimulates the secretion of IL-2 and IFN-γ by human primary T cells, making it useful for immunological research.