(1S,2S,3R) -PLX-4545
(1S,2S,3R) -PLX-4545 is the (1S,2S,3R) enantiomer of PLX-4545. This compound is an orally active and selective cereblon-based molecular glue degrader targeting IKZF2 (zinc finger transcription factor Helios) . PLX-4545 reprograms immunosuppressive regulatory T cells into pro-inflammatory effector T cells, thereby enhancing the anti-tumor immune response.
Product Specifications
CAS Number
2892066-42-9
Smiles
O ([C@@H]1[C@H] (CCCC1) N2CC (C2) C3=CC=CC=C3) C=4C=C5C (=CC4) C (=O) N (C5) [C@H]6C (=O) NC (=O) CC6
Molecular Formula
C28H31N3O4
Molecular Weight
473.57
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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