CT-133
CT-133 is a selective and potent antagonist of the CRTH2 Receptor, with a Ki value of 2.2 nM, and exhibits a Ki greater than 3800 nM for the DP1 receptor. It inhibits PGD2-induced neutrophil migration and significantly reduces lung inflammation and improves lung function impairment in a mouse model of acute lung injury (ALI) induced by cigarette smoke. Additionally, CT-133 effectively suppresses the overexpression of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) and the chemokine (KC) while reversing the suppression of the anti-inflammatory factor IL-10. CT-133 is useful for ALI research.
Product Specifications
CAS Number
2417155-47-4
Smiles
C (C (O) =O) C1=C2N (C=3C1=CC=CN3) C[C@H] (N (S (=O) (=O) C4=CC=C (F) C=C4) C) CC2.[Na]
Molecular Formula
C20H21FN3NaO4S
Molecular Weight
441.45
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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