Benzazepinoquinoline-spermine

Benzazepinoquinoline-spermine (Compound PA-3) is a potent complexing agent for pre-miR-372 that specifically inhibits its processing mediated by Dicer, with an IC50 of 0.58 μM. It exhibits strong affinity for pre-miR-372, with a KD of 0.11 μM, and shows high activity against pre-miR-373 (IC50= 0.29 μM) . However, its inhibitory effect is significantly reduced for pre-miR-17, pre-miR-21, and pre-miR-155, with IC50 values of 0.84 μM, 1.43 μM, and 1.07 μM, respectively. Benzazepinoquinoline-spermine is applicable in cancer research.