Nurr1/RXR agonist 1
Nurr1/RXR dual agonist 1 is a dual activator of Nurr1 (EC50 = 2.6 μM) and RXR, with Ks values of 0.6 and 1.1 μM, respectively. It disrupts the stability of Nurr1 homodimers selectively while stabilizing Nurr1:RXR heterodimers, specifically activating the heterodimer response element DR5. In neuronal cells, Nurr1/RXR dual agonist 1 enhances the expression of neuroprotective Nurr1 target genes without inducing genes associated with off-target effects. This compound is applicable in studies related to neurodegenerative diseases.
Product Specifications
CAS Number
2231746-53-3
Smiles
O=C (O) CC1=CC=C (C=C1) N2C (=C (C3=C2CCC (F) (F) C3) C) C
Molecular Formula
C18H19F2NO2
Molecular Weight
319.35
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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