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OPN-9643

OPN-9643 is a covalent inhibitor that targets the central palmitoyl-binding pocket of TEADs, with an IC50 of 15 nM. It prevents auto-palmitoylation and reduces TEAD-driven luciferase activity, as well as classic TEAD target genes such as CTGF and CYR61. OPN-9643 is applicable in cancer research, including studies on melanoma.

Product Specifications

CAS Number

2866423-06-3

Smiles

O=C (C=C) N1CC2=CC (OC3=CC=C (C=C3) C (F) (F) F) =CC=C2CC1

Molecular Formula

C19H16F3NO2

Molecular Weight

347.34

Storage Conditions

-20°C

Notes

For research use only.

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