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VK4-116

VK4-116 (Compound 19) is a selective dopamine D3 receptor (D3R) antagonist with a Ki of 6.84 nM. It significantly inhibits oxycodone-induced hyperactivity and locomotor sensitization in mouse models. Additionally, VK4-116 pretreatment suppresses the acquisition of oxycodone-induced conditioned place preference (CPP) in rat models.

Product Specifications

CAS Number

1982347-43-2

Smiles

O=C (NCCC (O) CN1CCN (C2=CC (=CC (Cl) =C2OC) CC) CC1) C3=CC=4C=CC=CC4N3

Molecular Formula

C26H33ClN4O3

Molecular Weight

485.03

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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