Antibacterial agent 301

Antibacterialagent 301 (compound 14c) is a pyridinecarboxamide derivative of pleuromutilin, exhibiting broad-spectrum antibacterial activity as well as significant antimycoplasmal effects. It inhibits the peptidyl transferase center (PTC), disrupts biofilms, and damages the cell membranes of multi-drug resistant (MDR) bacteria. In a murine model of systemic methicillin-resistant Staphylococcus aureus (MRSA) infection, Antibacterialagent 301 demonstrated efficacy. It can be used in research on multi-drug resistant bacterial infections.