FXR agonist 15

FXR agonist15 is a selective, potent, orally active farnesoid X receptor (FXR) agonist with an EC50 of 0.76 μM. It does not significantly activate other nuclear receptors such as LXRα/β, PXR, PPARα/β/γ, and THR-β, with EC50 values exceeding 10 μM for each. FXR agonist15 is effective in alleviating symptoms like steatosis, lobular inflammation, hepatocellular ballooning, and liver fibrosis. It is applicable in research studies related to non-alcoholic steatohepatitis (NASH) .