MPXV p37 protein-IN-1

MPXV p37 protein-IN-1 is a potent and orally effective inhibitor of the monkeypox virus (MPXV) p37 protein. It exhibits significant antiviral activity against MPXV, with an EC50 of 12.14 nM, and shows low cytotoxicity (CC50= 304.63 μM) . In mice, MPXV p37 protein-IN-1 demonstrates low toxicity and good tolerability. This compound can be utilized for research into anti-monkeypox virus drugs.