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Antitrypanosomal agent 27

Antitrypanosomal agent 27 (Compound 5c) is a quinazoline derivative with antitrypanosomal activity. It inhibits Trypanosoma brucei (T.b. brucei) with a GI50 value of 31 nM. The compound exhibits a selectivity index of ≥50 towards human liver cancer HepG2 cells and demonstrates no significant cytotoxicity. Antitrypanosomal agent 27 is applicable in the study of human African trypanosomiasis.

Product Specifications

CAS Number

2148927-96-0

Smiles

N1=CN=C (NC2=NC=CO2) C3=CC (=CC=C13) C=4C=CC=C (C4) N5CCOCC5

Molecular Formula

C21H19N5O2

Molecular Weight

373.42

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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