Antitrypanosomal agent 27

Antitrypanosomal agent 27 (Compound 5c) is a quinazoline derivative with antitrypanosomal activity. It inhibits Trypanosoma brucei (T.b. brucei) with a GI50 value of 31 nM. The compound exhibits a selectivity index of ≥50 towards human liver cancer HepG2 cells and demonstrates no significant cytotoxicity. Antitrypanosomal agent 27 is applicable in the study of human African trypanosomiasis.