EGFR/BRAFV600E-IN-6

EGFR/BRAFV600E-IN-6 (Compound 7c) is a dual inhibitor of EGFR and BRAFV600E, with IC50 values of 0.12 μM and 0.05 μM, respectively. It exhibits antiproliferative activity against HT-29, MCF-7, A549, and Panc-1 cells, with IC50 values of 8, 4, 6, and 7 μM. EGFR/BRAFV600E-IN-6 activates caspase-3/8/9, upregulates Bax expression, and downregulates Bcl-2 levels, inducing apoptosis and exhibiting antioxidant properties. It is applicable in cancer research, such as studies on colon cancer.