ETI60
ETI60 is an orally active selective TLR inhibitor that targets the nucleoside-binding sites I of TLR7 (IC50 = 0.68 μM) and TLR9 (IC50 = 0.12 μM) without affecting surface TLRs (including TLR1/TLR2, TLR2/TLR6, TLR4, and TLR5) . It demonstrates nanomolar activity in cell-based, biophysical, and in vivo assays, effectively inhibiting endosomal TLR-mediated pro-inflammatory signaling. ETI60 modulates the expression of genes related to inflammation and significantly improves symptoms in mouse models of psoriasis and systemic lupus erythematosus (SLE) . ETI60 is applicable in studies related to autoimmune and inflammatory diseases.
Product Specifications
CAS Number
2773475-11-7
Smiles
N1=C2C (=C (N) C3=C1CCCC3) C=4C=CC (OC) =CC4N2CCCN (C) C
Molecular Formula
C21H28N4O
Molecular Weight
352.48
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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