Tubulin polymerization/P-gp-IN-1

Tubulin polymerization/P-gp-IN-1 is a dual inhibitor targeting both tubulin polymerization and P-gp. It disrupts tubulin polymerization, inducing G2/M phase arrest and apoptosis (apoptosis) . By inhibiting P-gp's efflux function, it reverses multidrug resistance (MDR) . Tubulin polymerization/P-gp-IN-1 has dual roles: direct antitumor activity and reversal of P-gp-mediated cisplatin resistance. It binds stably to the tubulin CBS domain (ΔG = −12.4 kcal/mol) and the P-gp hydrophobic cavity (ΔG = −10.8 kcal/mol) . Tubulin polymerization/P-gp-IN-1 is applicable for research on drug-resistant cervical cancer.