Tau Protein Phosphorylation-IN-1

Tau ProteinPhosphorylation-IN-1 is a tau protein phosphorylation inhibitor that effectively protects PC12 cells from Aβ25-35-induced cytotoxicity (EC50 = 1.93 μM) and is capable of crossing the blood-brain barrier. It reverses tau protein hyperphosphorylation both in vitro and in vivo, significantly suppresses the expression of immune-related cytotoxic factors, blocks the MAPK and NF-κB signaling pathways, and reduces the levels of RAGE and apoptosis factor Bax/Bcl-2. In Alzheimer's disease mouse models, Tau ProteinPhosphorylation-IN-1 alleviates neuronal damage and improves learning and memory capabilities. It is applicable for Alzheimer's disease research.