Angustilongine M
Angustilongine M is a microtubule-targeting antitumor alkaloid with an IC50 of 0.2 μM against HT-29 cells. It induces G0/G1 phase cell cycle arrest and mitochondrial apoptosis by promoting microtubule polymerization. Angustilongine M shows potential for research in colorectal and other solid tumors.
Product Specifications
CAS Number
2732914-43-9
Smiles
C[C@H]1C=2C=3C4=C (N (C) C3C=CC2O[C@]5 ([C@@]1 ([C@]6 ([C@@] (CO5) ([C@@]7 (CC8=C ([C@] (C6) (N7C) [H]) N (C) C=9C8=CC=CC9) [H]) [H]) [H]) [H]) [H]) [C@]%10 ([N@@]%11[C@@] (C4) ([C@H] (CO) [C@] (C%10) (/C (=C\C) /C%11) [H]) [H]) [H]
Molecular Formula
C41H48N4O3
Molecular Weight
644.86
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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