Ferroptosis inducer-11

Ferroptosisinducer-11 is an agent that induces ferroptosis, exhibiting significant cytotoxicity against HCT-116, NCM-60, and HT-29 cells with IC50 values of 0.43 μM, 3.14 μM, and 0.48 μM, respectively. It potently inhibits GPX4 enzyme activity with an IC50 of 1.86 μM. This compound induces ferroptosis and increases lipid ROS, malondialdehyde (MDA), and Fe2+ levels in colon cancer cells while reducing glutathione (GSH) levels. Ferroptosisinducer-11 is useful for colon cancer research.