Columbin
Columbin is an orally active diterpenoid furanolactone from Calumbae radix, has anti-inflammatory and anti-trypanosomal effects. Columbin selectively inhibits COX-2 (EC50=53.1 μM) over COX-1 (EC50=327 μM) [1][2].
Product Specifications
CAS Number
[546-97-4]
UNSPSC
12352005
Hazard Statement
H315, H319
Target
COX; Parasite
Type
Natural Products
Related Pathways
Anti-infection; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Columbin.html
Purity
99.86
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1[C@](C=C2)(O)[C@@](CC3)(C)[C@@]([C@@](C[C@@H](C4=COC=C4)O5)(C)[C@]3([H])C5=O)([H])[C@]2([H])O1
Molecular Formula
C20H22O6
Molecular Weight
358.39
Precautions
H315, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N0389/Columbin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N0389/Columbin-SDS-MedChemExpress.pdf
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
COX-1; COX-2; Trypanosoma
Available Sizes
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