NCT-503
NCT-503 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 2.5 µM.
Product Specifications
CAS Number
[1916571-90-8]
UNSPSC
12352005
Hazard Statement
H315
Target
Phosphoglycerate Dehydrogenase (PHGDH)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/NCT-503.html
Concentration
10mM
Purity
99.69
Solubility
DMSO : 50 mg/mL (ultrasonic) |Ethanol : 13.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
S=C(N1CCN(CC2=CC=C(C(F)(F)F)C=C2)CC1)NC3=NC(C)=CC(C)=C3
Molecular Formula
C20H23F3N4S
Molecular Weight
408.48
Precautions
H315
References & Citations
[1]Pacold ME, et al. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nat Chem Biol. 2016 Jun;12 (6) :452-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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