NCT-503
Product Specifications
UNSPSC Description
NCT-503 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 2.5 µM.
Target Antigen
Phosphoglycerate Dehydrogenase (PHGDH)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/NCT-503.html
Purity
99.85
Solubility
DMSO : 50 mg/mL (ultrasonic)|Ethanol : 13.33 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
S=C(N1CCN(CC2=CC=C(C(F)(F)F)C=C2)CC1)NC3=NC(C)=CC(C)=C3
Molecular Weight
408.48
References & Citations
[1]Pacold ME, et al. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nat Chem Biol. 2016 Jun;12(6):452-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-101966/NCT-503-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-101966/NCT-503-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1916571-90-8
Available Sizes
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