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A2793

A2793 is an efficient dual TWIK-related acid-sensitive K+ channel (TASK) -1/TRESK inhibitor, with an IC50 of 6.8 μM for mTRESK. A2764 is more selective for TRESK, and it only moderately influences TREK-1 and TALK-1[1].

Product Specifications

CAS Number

88349-90-0

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/a2793.html

Concentration

10mM

Purity

98.55

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(OCC)COC1=C2N=CC=CC2=C(Cl)C=C1

Molecular Formula

C13H12ClNO3

Molecular Weight

265.69

Precautions

H315, H319, H335

References & Citations

[1]Miklós Lengyel, et al. Chemically Modified Derivatives of the Activator Compound Cloxyquin Exert Inhibitory Effect on TRESK (K 2P 18.1) Background Potassium Channel. Mol Pharmacol. 2019 Jun;95 (6) :652-660.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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