A2793
A2793 is an efficient dual TWIK-related acid-sensitive K+ channel (TASK) -1/TRESK inhibitor, with an IC50 of 6.8 μM for mTRESK. A2764 is more selective for TRESK, and it only moderately influences TREK-1 and TALK-1[1].
Product Specifications
CAS Number
88349-90-0
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/a2793.html
Concentration
10mM
Purity
98.55
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OCC)COC1=C2N=CC=CC2=C(Cl)C=C1
Molecular Formula
C13H12ClNO3
Molecular Weight
265.69
Precautions
H315, H319, H335
References & Citations
[1]Miklós Lengyel, et al. Chemically Modified Derivatives of the Activator Compound Cloxyquin Exert Inhibitory Effect on TRESK (K 2P 18.1) Background Potassium Channel. Mol Pharmacol. 2019 Jun;95 (6) :652-660.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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