(2R,4S) -1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate

(2R,4S) -1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate is a non-degradable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . (2R,4S) -1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate is also an alkyl-chain-based PROTAC linker used to prepare PROTAC molecules that mediate the degradation of target proteins. (2R,4S) -1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate can also serve as an organic synthesis intermediate in medicinal chemistry for the construction and modification of molecules containing proline structures.