JNK3 inhibitor-4
Product Specifications
UNSPSC Description
JNK3 inhibitor-4 is a potent inhibitor of JNK3 (IC50=1.0 nM) based on 2-aryl-1-pyrimidinyl-1H-imidazole-5-yl acetonitrile. JNK3 inhibitor-4 shows excellent selectivity over other protein kinases including isoforms JNK1 (IC50=143.9 nM) and JNK2 (IC50=298.2 nM)[1]. JNK3 inhibitor-4 has neuroprotective effect and predicated blood-brain barrier permeability[1].
Target Antigen
JNK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/jnk3-inhibitor-4.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#CCC1=CN=C(N1C2=NC(N[C@H]3CCCN(C3)C(C4CC4)=O)=NC=C2)C5=CC6=C(C=C5)C=CC=C6
Molecular Weight
477.56
References & Citations
[1]Jun J, et al. Discovery of novel imidazole chemotypes as isoform-selective JNK3 inhibitors for the treatment of Alzheimer's disease. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114894.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-151929/JNK3-inhibitor-4-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-151929/JNK3-inhibitor-4-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2409109-65-3
Available Sizes
Curated Selection
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