JNK3 inhibitor-4

JNK3 inhibitor-4 is a potent inhibitor of JNK3 (IC50=1.0 nM) based on 2-aryl-1-pyrimidinyl-1H-imidazole-5-yl acetonitrile. JNK3 inhibitor-4 shows excellent selectivity over other protein kinases including isoforms JNK1 (IC50=143.9 nM) and JNK2 (IC50=298.2 nM) [1]. JNK3 inhibitor-4 has neuroprotective effect and predicated blood-brain barrier permeability[1].

Product Specifications

CAS Number

[2409109-65-3]

UNSPSC

12352005

Target

JNK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/jnk3-inhibitor-4.html

Purity

99.37

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N#CCC1=CN=C(N1C2=NC(N[C@H]3CCCN(C3)C(C4CC4)=O)=NC=C2)C5=CC6=C(C=C5)C=CC=C6

Molecular Formula

C28H27N7O

Molecular Weight

477.56

References & Citations

[1]Jun J, et al. Discovery of novel imidazole chemotypes as isoform-selective JNK3 inhibitors for the treatment of Alzheimer's disease. Eur J Med Chem. 2023 Jan 5;245 (Pt 1) :114894.